Recently, the scientific and technological innovation team of livestock nutrition and regulation of Beijing Institute of animal husbandry and veterinary medicine, Chinese Academy of Agricultural Sciences, studied and revealed the molecular mechanism of Xylooligosaccharides to improve the intestinal barrier and immune function of weaned piglets by optimizing intestinal flora, which provided a theoretical basis for improving the disease resistance of weaned piglets and promoting efficient and healthy pig breeding. Relevant research was published in”carbohydrate polymers”.
In the context of”Prohibition of resistance”, the problems of diarrhea and low disease resistance of weaned piglets are prominent, causing huge economic losses to the pig industry. The research team combed the application value of Xylooligosaccharides in improving the disease resistance of piglets in the early stage, and found that Xylooligosaccharides can enhance the intestinal health of weaned piglets by improving intestinal barrier and regulating intestinal immunity, but the specific mechanism of action is not clear.
This study further revealed that Xylooligosaccharides can enhance the intestinal barrier function and regulate the specific regulatory mechanism of intestinal immunity in two aspects:first, Xylooligosaccharides can increase beneficial bacteria such as Lactobacillus, reduce potential pathogens, and then enhance the integrity of the intestinal barrier, inhibit the expression of proinflammatory cytokines, resulting in the weakening of the production process of immunoglobulin A and the antigen cross presentation process; Second, Xylooligosaccharides through notch and Wnt/β- The catenin signaling pathway regulates the proliferation or apoptosis of intestinal epithelial cells and the differentiation of intestinal goblet cells, and reshapes the energy metabolism pathway.
The research was supported by the National Natural Science Foundation of China and the innovation project of the Chinese Academy of Agricultural Sciences.