Recently, the nutritional feed and environment innovation team of the Institute of animal husbandry and veterinary medicine of Shandong Academy of Agricultural Sciences published a research paper entitled”protective effect of resveratrol against hydrogen peroxide induced oxidative stress in bovine skeletal muscle cells” in the internationally renowned academic journal”meet science” (if=7.077/q1), which clarified the mechanism of resveratrol in alleviating oxidative damage of beef cattle muscle cells, It lays a theoretical foundation for the application of resveratrol in beef production and improving beef quality.
With the improvement of people’s living standards, the demand for beef quality is higher and higher. Under the existing production conditions in China, beef cattle are prone to oxidative stress due to improper management in the process of feeding and slaughtering, resulting in the production of low-quality beef (such as black cut meat), which brings huge economic losses to the industry. Resveratrol is a non flavonoid polyphenol compound, which is a plant antitoxin produced by plants under biological or abiotic stress. It has the potential to resist stress and improve the redox state of the body, but the mechanism of action is unknown. Based on this, this study first explored the regulatory effect of resveratrol on oxidative stress in beef cattle muscle cells from the molecular and cellular level, and found that resveratrol has a positive regulatory effect in reducing the level of cellular reactive oxygen species free radicals, improving antioxidant capacity and improving cell activity. Subsequently, the study focused on sirt1/foxos and keap1/nrf2 signaling pathways, and found that the main way for resveratrol to play a regulatory role was keap1/nrf2 signaling pathway. Finally, the key genes of keap1/nrf2 signal pathway were silenced by RNA interference technology. Finally, it was found that the mechanism of resveratrol was mainly related to the direct regulation of downstream gene expression of this signal pathway.
Dr. zhangxianglun is the first author of this paper, and liuguifen and zhaohongbo are the corresponding authors. The research was supported by Shandong Provincial Natural Science Foundation (zr2017bc043), the Academy’s innovation project”key technologies for improving quality and efficiency of intelligent livestock and poultry breeding” (cxgc2021a14), the National Natural Science Foundation of China (31772649) and other projects.