Recently, the aquatic product quality safety and Processing Laboratory of the East China Sea Fisheries Research Institute of the Chinese Academy of Fishery Sciences has made a series of achievements in the accumulation, transmission and transformation characteristics of polychlorinated biphenyls (PCBs) metabolites during dietary exposure. The two achievements were published in the international authoritative journal enviroNational pollution (jcr1 area, if:9.988) and science of the total environment (JCR 1 area, if:10.753). Associate researcher Shi Yongfu, the corresponding author of the article, has long been concerned about the hidden dangers and impacts of environmental pollutants on the quality and safety of aquatic products. He and his team members have long focused on the identification of metabolites of PCBs in typical aquatic species, the accumulation, transformation and transmission characteristics of PCBs metabolites after simulated exposure, and the study of toxicological effects and mechanisms. The phased research results have been recognized in the same field internationally.
PCBs are a kind of environmental persistent pollutants prohibited by Stockholm Convention, which have cumulative toxicity such as carcinogenicity, teratogenicity and mutagenicity. They can migrate and persist in the environment through atmospheric sedimentation, rainwater scouring, surface runoff and other ways. The aquatic environment is one of the main reservoirs of PCBs. In addition to a large number of studies on PCBs itself, domestic and foreign researchers have carried out a lot of research, including the identification of metabolites in aquatic organisms The transmission characteristics and the hidden dangers of metabolites on the quality and safety of aquatic products have gradually attracted attention, especially the accumulation and transformation characteristics of metabolites in the consumer population after dietary exposure are scientific issues that need to be studied in depth. Based on this, the research group of Shi Yongfu, an associate researcher, has carried out continuous in-depth research.
In order to study the metabolism of PCBs in typical aquatic species, the research group selected pcb101, one of the indicative polychlorinated biphenyls, to expose crucian carp by single intraperitoneal injection. At different stages after exposure, the metabolites in various tissues were identified to determine their metabolic pathways and final products. It is found that pcb101 can metabolize at least three kinds of metabolites in crucian carp, including hydroxyl, methanesulfonyl and methoxy metabolites, of which hydroxyl metabolites account for the highest proportion. The accumulation characteristics of metabolites in various tissues are described. The research results are published in enviroNational pollution; On this basis, in order to further study the accumulation and transformation characteristics of the main metabolite Oh PCBs after human intake of aquatic products, the research group prepared a feed from Crucian Carp containing a certain concentration of Oh PCBs, exposed mice to food, and simulated the metabolism and transformation characteristics of people after daily intake of aquatic products. The study found that oh PCBs will be transformed into methanesulfonyl and methoxy polychlorinated biphenyls after entering the model organism, and it was the first time to find that oh-pcb101 will be inversely transformed into the parent compound pcb101 in the model organism, which provides a new perspective for the reason why polychlorinated biphenyls can persist. The research results were published in science of the total environment.
At present, the research on the impact of PCBs on the quality and safety of aquatic products in China mostly focuses on the detection of the content of parent compounds in aquatic products. This study confirms that PCBs can be further metabolized or mutually transformed in aquatic organisms, and the hidden dangers caused by their metabolites on the quality and safety of aquatic products have not been paid enough attention. At present, the safety limit of domestic PCBs standard only stipulates parent compounds. The research results can provide research support for the formulation of relevant norms and standards of food safety, and are of great significance to comprehensively improve the quality and safety level of aquatic products in China. This work has been supported by the National Natural Science Foundation of China, the special funds of the Ministry of agriculture and rural areas, and basic scientific research business fees.