EU evaluates the safety of a food enzyme containing four enzyme activities
By: Date: 2022-07-25 Categories: newsguide Tags: ,
   Food partner online news  2022年7月22日,欧盟食品安全局就一种含有四种酶活性的食品酶的安全性评价发布意见。

It is understood that this food enzyme contains endo polygalacturonase, pectinesterase, pectin lyase and non reducing end α- L-arabinofuranase has four activities, which are produced by Aspergillus niger strain PEC. It is used for the manufacture of alcoholic beverages from fruits other than grapes, the processing of fruits and vegetables for fruit juice production, and the production of wine and wine vinegar.
After evaluation, the expert group believes that under the expected use conditions, the risk of allergy and induced reaction caused by dietary exposure cannot be excluded, especially for individuals sensitive to several pollen allergens or Papaya allergens. Based on the data provided, the team concluded that the food enzyme would not cause safety hazards under the expected conditions of use. Some original reports are as follows:
  The food enzyme has four declared activities (endo-polygalacturonase ((1→4)- α- d-galacturonan glycanohydrolase (endo-cleaving);, pectinesterase (pectin pectylhydrolase;, pectin lyase ((1→4)-6-O-methyl- α- d-galacturonan lyase; and non-reducing end α- l-arabinofuranosidase ( α- l-arabinofuranoside non-reducing end α- l-arabinofuranosidase; and is produced with the non-genetically modified Aspergillus niger strain PEC by DSM Food Specialties B.V. The food enzyme is free from viable cells of the production organism. The food enzyme is intended to be used in the manufacture of alcoholic beverages from fruits other than grapes, fruit and vegetable processing for juice production, and wine and wine vinegar production. Dietary exposure was estimated to be up to 0.25 mg TOS/kg bodyweight (bw) per day in European populations. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 204 mg TOS/kg bw per day, the highest dose tested which, when compared with the estimated dietary exposure, results in a margin of exposure of at least 800. A search for similarity of the amino acid sequence of the food enzyme to known allergens was made and several matches were found. The Panel considered that, under the intended conditions of use, the risk of allergic sensitisation and elicitation reactions by dietary exposure cannot be excluded, particularly for individuals sensitised to several pollen allergens or papaya allergens. based on the data provided, the Panel concluded that this food enzyme did not give rise to safety concerns, under the intended conditions of use.
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