Recently, Zheng Jusheng’s research group from the School of Life Sciences of West Lake University published a titled Multi-omics analyses reveal relationships among dairy consumption, gut microbiota and cardiomeThe latest achievement of tabolic health. This study uses multi-omics to reveal the beneficial effects of long-term intake of dairy products on the composition and structure of the human intestinal flora. At the same time, it is the interaction between the intake of dairy products and the intestinal flora and the cardiovascular system. The link to metabolic health provides new insights. 2018 doctoral student Shuai Menglei and Sun Yat-sen University master student Zuo Luo Shiyuan are the co-first authors, and Dr. Zheng Jusheng from West Lake University and Dr. Chen Yuming from Sun Yat-Sen University are the co-corresponding authors of this article (Figure 1). Paper link:https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(21)00077-3/fulltext
More and more evidences show that the homeostasis of the gut microbiota is closely related to human health. Although the intestinal flora can quickly respond to diet within a few days, long-term eating habits may play a leading role in shaping the structure and composition of the intestinal flora. Dairy products are a common food type in our lives. However, the relationship between dairy products and cardiovascular and metabolic diseases still remains controversial. At present, there are only a few small-scale cross-sectional population studies or short-term intervention trials that have explored the impact of dairy products intake on the intestinal flora. There is no prospective cohort study to explore whether dairy products can improve human metabolism by regulating the intestinal flora. health.
In addition, for people with relatively low intake of dairy products, especially the Chinese population, little is known about whether increasing dairy intake can improve the composition of the intestinal flora and its impact on host metabolic health. The relationship between dairy-related intestinal flora characteristics and cardiovascular metabolic risk factors has not yet been elucidated.
Guangzhou Nutrition and Health Cohort is a Chinese Han Chinese middle-aged and elderly population cohort (45-75 years old) containing more than 4,000 participants. Starting from the baseline recruitment in 2008-2013, Zheng Jusheng’s team and the cooperative team competed every three years. Participants were followed up. After about 6 years of long-term follow-up, the team collected stool samples from about 2,000 people and performed DNA sequencing analysis of the intestinal flora. At the same time, this study also collected information such as population medication and diet questionnaires to analyze the relationship between long-term dairy product intake (mainly including milk and yogurt), intestinal flora, and cardiovascular and metabolic health.
In this large prospective cohort study, Zheng Jusheng’s team found that the intake of dairy products is closely related to the diversity of intestinal flora. The more dairy products are consumed, the higher the alpha diversity of the intestinal flora. Microbial scores related to dairy product intake are negatively correlated with blood triglycerides, and positively correlated with high-density lipoprotein cholesterol (Figure 2). Further metabolomics analysis showed that the intestinal microbiota related to dairy product intake may affect the host’s circulating metabolism profile, thereby reducing the level of cardiovascular risk factors.
Compared with developed countries, China’s current per capita intake of dairy products is still far behind, and it has not reached the recommended standard (300 g/d) of the 2016 Chinese Dietary Guidelines for Residents. The results of this study, mainly based on the Chinese population, show that long-term intake of dairy products has a beneficial effect on the structure and composition of the intestinal microbiota. The consumption of dairy products (milk, yogurt, etc.) should be encouraged to create a good intestinal flora Environment to prevent the risk of potential cardiovascular and metabolic diseases caused by low dairy product intake. The intestinal microbial characteristics and circulating metabolite biomarkers found in the study that are related to the intake of dairy products can also be used as potential treatment or intervention targets for future cardiovascular and metabolic diseases.