Tianjin University of Science and Technology has made new progress in antagonizing heavy metal hazards by food-borne functional factors
By: Date: 2021-04-11 Categories: foodtechnology Tags: ,
   Recently, the State Key Laboratory of Food Nutrition and Safety of Tianjin University of Science and Technology has made a breakthrough in the antagonistic effect of chlorogenic acid on food-borne cadmium. chlorogenic acid and 3-(3-hydroxyphenyl) propionic acid against cadmium-induced erythrocyte cytotoxicity:in vitro and in vivo evaluation” was published in the Journal of Agricultural and Food chemistry, a top journal in the field of agricultural and forestry sciences . Associate Professor Cheng Dai is the first author and corresponding author of the paper, and Tianjin University of Science and Technology is the first signatory.
   Cadmium pollution in the environment is an important source of cadmium exposure risk in the population. The absorption of cadmium into the human body will cause significant red blood cell damage. Finding efficient and safe food ingredients allows people to adjust their daily diet in a targeted manner It is extremely urgent to reduce the biological toxicity caused by cadmium exposure. Previous studies have shown that dietary intervention of chlorogenic acid can improve the distribution of intestinal flora in cadmium-exposed mice, and effectively reduce the accumulation of cadmium in the tissues of the model group of mice (JAFC, 2021, 69, 5, 1675–1683). However, the contribution of the intestinal microbial catabolites of dietary intake of chlorogenic acid to the antagonistic effect of cadmium exposure remains unclear.
  In response to this basic scientific problem, researchers used 3-(3-hydroxyphenyl)propionic acid (HPPA) as a representative substance of the end product of chlorogenic acid intestinal metabolism, and established in vivo and in vitro cadmium exposure models to compare The protective effect of chlorogenic acid and HPPA on red blood cells. The results show that in the process of red blood cell damage caused by cadmium exposure in vivo and in vitro, 3-(3-hydroxyphenyl)propionic acid and chlorogenic acid can effectively reduce the accumulation of cadmium and inhibit the PKC signal pathway, thereby improving cadmium. Membrane damage to red blood cells. Compared with chlorogenic acid, HPPA has a stronger protective effect on red blood cell damage, which reflects the important role of intestinal microbes in the catabolism of chlorogenic acid in the process of antagonizing cadmium. The theoretical innovation of the antagonistic mechanism of food-derived phenolic compounds to cadmium exposure provides research ideas for other phenolic substances to antagonize the harm of heavy metals.
  The research results were funded by the National Natural Science Foundation of China (31801453), the Special Funding Project of the Postdoctoral Science Foundation of China (2018T110194), and the “Outstanding Young Talent Support Program” project of the State Key Laboratory of Food Nutrition and Safety.