Recently, Professor Liang Hui’s team from the School of Public Health of Qingdao University has made new progress in the field of fucoidan in the prevention of colorectal tumors and alleviation of alcoholic liver injury. The related research results are based on two papers”Effects of fucoidan on gut flora” and tumor prevention in 1,2-dimethylhydrazine-induced colorectal carcinogenesis”,”Protective effects of fucoidan against ethanol-induced liver injury through maintaining mitochondria function and mitophagy balance in rats.” (DOI:10.1039/D0FO03220D) respectively Published in the journals The Journal of Nutritional Biochemistry (IF=4.873, SCI area two) and Food & Function (IF=4.171, SCI area one). Professor Liang Hui is the corresponding author of the two articles. Teacher Xue Meilan and PhD student Zhao Huichao are the first authors of the two articles respectively.
The research was funded and supported by the National Natural Science Foundation of China (No. 81872605, No. 81573137, No. 81502298), the Major Science and Technology Innovation Project of Shandong Province (2019JZZY010818), and the Natural Science Foundation of Shandong Province (No. ZR2020MH215) .
”Effects of fucoidan on gut flora and tumor prevention in 1,2-dimethylhydrazine-induced colorectal carcinogenesis” research found that dietary fucoidan can prevent colorectal tumors by regulating the intestinal microecology and immune function. The mechanism is related to the activation of Hippo pathway by fucose, down-regulation of β-catenin pathway, inducing tumor cell apoptosis and inhibiting tumor growth.
”Protective effects of fucoidan against ethanol-induced liver injury through maintaining mitochondria function and mitophagy balance in rats.” The study found that alcohol-induced excessive oxidative stress inhibits mitochondrial function and promotes It damages the accumulation of mitochondria, stimulates PTEN-induced PINK1 and Parkin-related mitochondrial autophagy pathways, activates the mitochondrial dynamic-related protein Drp1, and promotes mitochondrial division. Fucoidan intervention can prevent alcohol-induced accumulation of mitochondrial damage and over-activated mitochondrial autophagy, which plays a key role in maintaining mitochondrial homeostasis and ensuring mitochondrial quality.
These new research findings provide a new strategy for the prevention of colorectal tumors and the treatment of alcoholic liver injury by fucoidan, and also provide a scientific basis for the rational use of nutritional supplements.