Professor Qi Xuefeng, Northwest A&F University College of Animal Science and Technology, has made new progress in the pathogenic mechanism of the major domestic animal disease-Peste des petits ruminants virus
By: Date: 2021-04-06 Categories: foodtechnology Tags: ,
  Recently, Professor Xuefeng Qi’s research group published a paper entitled”PPRV-induced novel miR-3 contributes to inhibit type I IFN production by targeting IRAK1″ in the authoritative journal”Journal of Virology” in the field of virology. Li Huan, a master’s student in the School of Veterinary Medicine of our school, and researcher Xue Qinghong from the China Institute of Veterinary Drug Supervision are the co-first authors. Professor Qi Xuefeng and Professor Wang Jingyu are the co-corresponding authors. Our school is the first to complete the thesis.
  Peste des petits ruminants (PPR) is an acute, severe, highly contagious infectious disease of small ruminants such as goats and sheep caused by the Peste des petits ruminants virus (PPRV), causing death The rate is high. The disease is listed as a Class A disease by the World Organization for Animal Health (OIE) and is also a Class I animal disease prescribed by my country. So far, more than 70 countries around the world have confirmed the discovery of Peste des petits ruminants in their territory. Since 2014, there have been PPR epidemics in 25 provinces, municipalities and autonomous regions in my country. The main characteristic of the pathogenicity of PPRV is the immunosuppression of the body after infection of the host, but its pathogenic mechanism is still unclear. Interferon plays a key role in the antiviral response. After PPRV infects the host, inhibiting the antiviral effect of interferon through a variety of ways is one of the key factors in its pathogenicity.
  Professor Qi Xuefeng’s research group has shown that the microRNA expression profile in the peripheral blood mononuclear cells of goats infected by PPRV has changed significantly. Further studies have found that PPRV can induce the expression of miR-3 in the peripheral blood mononuclear cells of goats, and miR-3 passes Directly target negative regulation of IRAK1 to inhibit the expression of IFN-α, thereby promoting the replication of PPRV in host cells.
   The research was funded by the National Natural Science Foundation of China (No.31572588, 31602035) and the 13th Five-Year National Key Research and Development Program (No.2017YFD0500902), and the PI team of Professor Zhang Yanming, a double first-class discipline group, Animal Biotechnology, Northwest A&F University support.
   Article link:https://doi.org/10.1128/JVI.02045-20