Our researchers successfully cloned the major gene of duck muscle fiber diameter
By: Date: 2021-04-08 Categories: foodtechnology Tags: ,
   Recently, the Waterfowl Breeding and Nutrition Technology Innovation Team of Beijing Institute of Animal Science and Veterinary Medicine, Chinese Academy of Agricultural Sciences successfully cloned the major gene TASP1 for duck breast muscle fiber diameter, and clarified the genetic mechanism of the gene regulating muscle fiber development. This research not only enriches the understanding of genetic regulation of duck muscle development, but also provides precise molecular markers for the selection of breast muscle fiber diameter in meat ducks. Related research results are published online in Heredity.
   Skeletal muscle is the most important part of the meat and poultry body, accounting for 40%-50%of body weight. Muscle fibers are the basic component of skeletal muscle, and the increase in muscle mass stems from the hypertrophy of muscle fibers after birth. In livestock and poultry production, the increase in muscle fiber diameter in muscle will significantly affect the yield and quality of meat.
  Researchers based on the isolated populations of mallard ducks and Beijing ducks, and through genome-wide association analysis, successfully located the major gene TASP1 that determines muscle fiber diameter. Through the comparison of the spatial and temporal transcriptome data of the breast muscles of Peking duck and wild duck, it was found that the difference in TASP1 gene expression gradually increased from the age of 1 day to 6 weeks of the fastest breast muscle development. After population homologous recombination analysis, the causal variation that affects the diameter of the muscle fiber was further finely mapped to the TASP1 gene, and the causal variation site was finally determined. The researchers also clarified the genetic mechanism by which the TASP1 gene regulates muscle fiber development, that is, the TASP1 gene encodes an endopeptidase to modify the MLL protein. When the TASP1 gene is mutated, the MLL protein cannot be modified correctly, which leads to the inhibition of related gene expression, and then Activate the function of muscle satellite cells, which eventually leads to the growth of muscle fibers.
   The research was funded by the Science and Technology Innovation Project of the Chinese Academy of Agricultural Sciences, the National Natural Science Foundation of China, and the National Waterfowl Industry Technology System. (Correspondent Fu Songchuan)
   link to the original text:https://www.nature.com/articles/s41437-021-00425-w
Our researchers successfully cloned the major gene of duck muscle fiber diameterimage
  Figure 1 Differences in muscle fiber diameter between varieties
Our researchers successfully cloned the major gene of duck muscle fiber diameterimage(1)< br/>
  Figure 2 Fine localization of muscle fiber diameter traits