Recently, the scientific and technological innovation team of conservation and utilization of livestock and poultry germplasm resources of Beijing Institute of Animal Husbandry and Veterinary Medicine, Chinese Academy of Agricultural Sciences focused on sheep germplasm resources evaluation, protection and key gene mining research , Taking the sheep breeds of different ecological environments (drought, humid, high altitude, low altitude, etc.) and different production purposes in China as the research object, based on the whole gene scanning method, the functional genes and related functional genes that affect the extreme environmental adaptability and production traits of sheep have been identified. change gender. This research provides an important scientific basis for the further protection and innovative use of local fine sheep germplasm resources in my country. Relevant research results were published in”Genes” and”Scientific Report”.
According to Associate Researcher Zhao Qianjun, my country has a vast territory and rich sheep resources. After a long period of A local sheep breed with excellent traits such as high fecundity. However, due to the introduction of foreign breeds, hybridization and inbreeding and other factors, local sheep breed resources have different degrees of genetic diversity and population decline. Therefore, it is necessary to develop effective population sizes and inbreeding coefficients for key sheep breeds (groups). Wait for evaluation work to identify genes that affect these key traits. The researchers took my country’s Oula sheep, Qinghai White Tibetan sheep, Hu sheep, Karakul sheep, and lowland sheep as the research objects, using high-density microarrays, resequencing and other methods to analyze the genetic diversity and genetic structure of the above-mentioned breeds. , Inbreeding coefficient, continuous homozygous segment (ROH), etc. were evaluated. Through selection signal analysis, genes and signal pathways related to important traits such as drought tolerance, high altitude adaptability, high fertility, growth and development, and coat color were further identified.
The research was supported by the Science and Technology Innovation Project of the Chinese Academy of Agricultural Sciences and the Technical Research System of Wool Sheep Industry Project.
Tibetan sheep selection signal analysis Manhattan map
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