Recently, the bee product processing and function evaluation team of the Institute of Bee Research, Chinese Academy of Agricultural Sciences found that the phenolic acid lipid compound”caffeic acid cinnamyl ester” in propolis can significantly improve the accumulation of lipids in liver cells and the secretion of inflammatory factors in fat cells It also reveals its molecular mechanism for regulating lipid metabolism disorders, which provides an important reference for propolis to assist in the treatment of lipid metabolism diseases. Related research results were published online in the journal Evidence-based Complementary and Alternative Medicine.
According to the team’s Dr. Kong Lingjie, lipid metabolism disorder is one of the important risk factors for atherosclerosis, coronary heart disease, stroke, fatty liver, diabetes and other diseases. As a natural bee product, propolis has received continuous attention in helping to improve lipid metabolism diseases because it is rich in a variety of phenolic components. The thesis evaluated and screened 8 phenolic acids and 8 phenolic acid ester compounds with lipid-lowering activity in propolis. Studies have found that phenolic acid ester compounds have higher lipid-lowering activity, especially caffeic acid cinnamon fat, caffeic acid phenethyl ester and caffeic acid benzyl ester. It was revealed for the first time that caffeic acid cinnamyl ester can significantly reduce the accumulation of lipids in liver cells by inhibiting the expression of PERK and ATF6 signaling pathway proteins under endoplasmic reticulum stress. And by up-regulating the expression of PPARα and down-regulating the expression of PPARγ to improve lipid metabolism disorders. This research provides a theoretical basis for the development of a new generation of propolis health care products that can prevent and treat fatty liver.
This research was funded by the Innovation Project of the Chinese Academy of Agricultural Sciences and the National Bee Industry Technology System Project.
link to the original text:https://doi.org/10.1155/2021/7615830