essential Omega-3 fatty acids (n-3 PUFA) are essential for the development and maturity of the brain. In epidemiological studies, maternal intake of n-3 PUFA is related to the reduction of a variety of neurological diseases, but the mechanism by which n-3 PUFA deficiency affects central nervous system development is poorly understood.
Recently, researchers in the United States and France have found in a study that n-3 PUFA deficiency in the mother’s diet can increase development by activating the 12/15-lipoxygenase (LOX)/12-HETE signaling pathway The phagocytosis of the hippocampal synaptic element microglia changes the morphology of neurons and affects the cognitive ability of offspring. The title of the article is:Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the developing brain.
The phagocytosis of synaptic elements by active microglia is an important process for normal brain development. Once the neuronal circuit is established, microglia will phagocytose the early postnatal synapses in a cascade-dependent way of chain protein and complement Contact elements, thereby helping to improve synaptic connections. The refinement of synapses is a sign of various neurodevelopmental disorders. Researchers found that n-3 PUFA deficiency in the maternal diet activates the 12/15-lipoxygenase (LOX)/12-HETE signaling pathway, changes the phenotype of microglia, and impairs the homeostasis of microglia The signal enhances its phagocytic activity, leads to synapse refinement and loss, affects the formation of neuronal circuits, changes the morphology of hippocampal neurons and hippocampal-mediated spatial working memory, resulting in abnormal behavior. This shows that specific dietary strategies can improve the activity of microglia, which is an effective way to prevent and treat developmental disorders of the nervous system.
link to the paper:https://www.biorxiv.org/content/10.1101/744136v1.full