Recently, Zhou Yong and others from the Yangtze River Fisheries Research Institute of the Chinese Academy of Fishery Sciences and others applied for”An oral vaccine and application of crucian hematopoietic organ necrosis yeast” won the national invention patent Authorized, the patent number is:ZL201910811945.4.
This invention discloses a yeast oral vaccine for hematopoietic necrosis of crucian carp and its application. The oral vaccine involved is Saccharomyces cerevisiae expressing the fusion protein LTB-ORF25. The protein has good immunogenicity and stability in crucian carp, and the vaccine has high protection. The survival rate of crucian carp after challenge is as high as 86.67%. After being made into an oral vaccine, the operation is simple and suitable for large-scale promotion.